BiallelicBglII DNA polymorphism of the human p53 oncogene

Study of the Human Mitochondrial DNA Polymorphism

The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses.

The p53 protein was first described 10 years ago in studies from three independent laboratories (Linzer and Levine, 1979; Lane and Crawford, 1979; DeLeo et a/., 1979). p53 was shown to form oligomeric protein complexes with the SV40 large tumor antigen (T antigen) in SV40-infected or -transformed cells (Linzer and Levine, 1979; Lane and Crawford, 1979). That the p53 protein was not encoded by S...

Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients Patients

Background: Hypercoagulability and hypofibrinolysis are among the symptoms exhibited by diabetic patients. Our study aimed to address the polymorphic nature of Alu DNA fragment in the human tissue plasminogen activator gene within diabetes mellitus (DM) Jordanian patients. Methods: Genomic DNA was isolated from 76 DM patients and 60 non-diabetic Jordanian individuals, and the Alu fragment was a...

Mouse models for the p53 R72P polymorphism mimic human phenotypes.

The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein. This polymorphism affects the apoptotic activity of p53 but the mechanistic basis and physiologic relevance of this phenotypic difference remain unclear. Here, we describe the development of mouse models for the p53 R72P SNP using ...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...